Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Parkes M, Barrett JC, Prescott NJ, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland. Van Limbergen J, Russell RK, Nimmo ER, et al. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. Evidence-based clinical practice guidelines for inflammatory bowel disease. Pathophysiology of inflammatory bowel disease: an overview.
Role of genetics in the diagnosis and prognosis of Crohn's disease. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. 68(4 Pt 1):627-35.ĭ'Haens G, Baert F, van Assche G, et al, for the Belgian Inflammatory Bowel Disease Research Group., North-Holland Gut Club. Clinical patterns in Crohn's disease: a statistical study of 615 cases. Practice parameters for the surgical management of Crohn's disease. Diagnostics of inflammatory bowel disease. Quality of life in children with Crohn's disease. Academic achievement, attendance, and school-related quality of life in pediatric inflammatory bowel disease. New York, NY: McGraw-Hill Professional Publishing 2001.
Tierney LM, McPhee SJ, Papadakis MA, eds. Crohn's disease: a review of current treatment with a focus on biologics. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, and Management. Feldman M, Scharschmidt BF, Sleisenger MH, eds.
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